 Fri Jun 21 14:21:30 2024, Oscar Ferrante, University of Birmingham, o.ferrante@bham.ac.uk, 12/31/25, Relating subcortical structures to the modulation of neocortical alpha and beta oscillations, ASP, , , , No, IN PROGRESS, ,
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 Mon Jun 24 09:15:10 2024, Oscar Ferrante, University of Birmingham, o.ferrante@bham.ac.uk, 12/31/25, Relating subcortical structures to the modulation of neocortical alpha and beta oscillations, ASP, , Ole Jensen, Ling Liu, Huan Luo, Liad Mudrik, MEG, No, IN PROGRESS, ,
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Mon Jun 24 09:17:11 2024, Oscar Ferrante, University of Birmingham, o.ferrante@bham.ac.uk, 12/31/25, Relating subcortical structures to the modulation of neocortical alpha and beta oscillations, ASP, , Tara Ghafari, Ole Jensen, , MEG, No, IN PROGRESS, ,
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It has recently been demonstrated that the thalamus and basal ganglia are related to the modulation of neocortical oscillatory activity (Mazzetti et al., 2019). In addition, research conducted on mice and non-human primates supports the theory that cortical-thalamic-basal-ganglia circuits play a significant role in generating and controlling neocortical oscillations (Cruz et al., 2023). Meanwhile, many neurological disorders, including Alzheimer’s and Parkinson’s Disease, are linked to structural changes in the subcortical regions (Cho et al., 2014).
The aim of this study is to investigate whether changes in subcortical structures are reflected in neocortical activity, specifically the modulation of alpha and beta band oscillations, as measured by resting-state MEG. To achieve this, we will develop tools to identify alpha and beta bursting during rest in healthy participants and quantify their hemispheric asymmetries. Next, the volumetric lateralization of subcortical regions will be evaluated and correlated with neocortical oscillations to establish a link between subcortical structures and oscillatory activity. For this purpose, we would like to request having access to the resting state MEG data from experiment one and two of the COGITATE study, along with the T1 MRI scans and eyetracking data.
This study will shed light on the role of subcortical structures in cognitive functions in relation to their ability to modulat oscillatory brain activity. It also has the potential to provide non-invasive electrophysiological methodology (MEG, EEG) for early diagnosis of neurological diseases affecting subcortical structures.
Overall, this study seeks to demonstrate the relationship between subcortical structures and oscillatory activity in the neocortex. This could lead to a better understanding of neurological disorders and contribute to the development of more effective diagnostic tools for the early detection of such diseases.
Mazzetti, C., Staudigl, T., Marshall, T. R., Zumer, J. M., Fallon, S. J., & Jensen, O. (2019). Hemispheric asymmetry of globus pallidus relates to alpha modulation in reward-related attentional tasks. Journal of Neuroscience, 39(46), 9221-9236.
Cruz, K. G., Leow, Y. N., Le, N. M., Adam, E., Huda, R., & Sur, M. (2023). Cortical-subcortical interactions in goal-directed behavior. Physiological reviews, 103(1), 347-389.
Cho, H., Kim, J. H., Kim, C., Ye, B. S., Kim, H. J., Yoon, C. W., ... & Seo, S. W. (2014). Shape changes of the basal ganglia and thalamus in Alzheimer's disease: a three-year longitudinal study. Journal of Alzheimer's disease, 40(2), 285-295.. |